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doi:10.1534/genetics.107.084566
A more recent version of this article appeared on April 1, 2008.
REGULAR RESEARCH PAPERS |
Defining regions and rearrangements of the Silene latifolia Y chromosome
Roberta Bergero 1, Deborah Charlesworth 1*, Dmitry A Filatov 2 and Richard C Moore 3
1 University of Edinburgh
2 University of Oxford
3 Miami University
* To whom correspondence should be addressed. E-mail: deborah.charlesworth{at}ed.ac.uk.
Submitted on November 15, 2007
Revised on December 27, 2007
Accepted on 17 January 2008
We combine data from published marker genotyping of three sets of S. latifolia Y chromosome deletion mutants with changed sex phenotypes, and add genotypes for several new genic markers, to refine the deletion map of the Y chromosome and compare it with the X chromosome genetic map. We conclude that the Y chromosome of this species has been derived through multiple rearrangements of the ancestral gene arrangement, and that none of the rearrangements so far detected was involved in stopping X-Y recombination. Different Y genotypes may also differ in their gene content and possibly arrangements, suggesting that mapping the Y-linked sex-determining genes will be difficult, even if many further genic markers are obtained. Even to determine the map of Y chromosome markers, so as to discover all the rearrangements, physical mapping by FISH or other experiments will be essential. Future deletion mapping work should ensure that markers are studied in the parents of deletion mutants, and should probably include additional deletions that were not ascertained by causing mutant sex phenotypes.
Key Words: Silene latifolia, Y chromosome, deletion map, hermaphrodite, inversion
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