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Originally published as Genetics Published Articles Ahead of Print on August 20, 2008.
Genetics, Vol. 180, 681-686, September 2008, Copyright © 2008
doi:10.1534/genetics.108.090704
Maintenance of Mitochondrial DNA by the Caenorhabditis elegans ATR Checkpoint Protein ATL-1
Chihiro Mori, Takako Takanami and Atsushi Higashitani1
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
1 Corresponding author: Graduate School of Life Sciences, Katahira 2-1-1, Sendai 980-8577, Japan.
E-mail: ahigashi{at}ige.tohoku.ac.jp
Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.