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Originally published as Genetics Published Articles Ahead of Print on August 20, 2008.
Genetics, Vol. 180, 301-316, September 2008, Copyright © 2008
doi:10.1534/genetics.108.089706
Hitchhiking Both Ways: Effect of Two Interfering Selective Sweeps on Linked Neutral Variation
Luis-Miguel Chevin*,
,1,
Sylvain Billiard
and
Frédéric Hospital
* UMR de Génétique Végétale, Ferme du Moulon, 91190 Gif sur Yvette, France, Ecologie, Systématique et Evolution, UMR 8079, Université Paris-Sud, 91405 Orsay Cedex, France, INRA, UMR1236 Génétique et Diversité Animales, 78352 Jouy-en-Josas, France and Génétique et Evolution des Populations Végétales, Université des Sciences et Technologies de Lille 1, F-59655 Villeneuve d'Ascq Cedex, France
1 Corresponding author: UMR 8079, Bât. 360, Université Paris-Sud, 91405 Orsay Cedex, France.
E-mail: luis-miguel.chevin{at}u-psud.fr
The neutral polymorphism pattern in the vicinity of a selective sweep can be altered by both stochastic and deterministic factors. Here, we focus on the impact of another selective sweep in the region of influence of a first one. We study the signature left on neutral polymorphism by positive selection at two closely linked loci, when both beneficial mutations reach fixation. We show that, depending on the timing of selective sweeps and on their selection coefficients, the two hitchhiking effects can interfere with each other, leading to less reduction in heterozygosity than a single selective sweep of the same magnitude and more importantly to an excess of intermediate-frequency variants relative to neutrality under some parameter values. This pattern can be sustained and potentially alter the detection of positive selection, including by provoking spurious detection of balancing selection. In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories.
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