TABLE S3

A classified summary of the inferred function of the products of 91 genes in the Adh region

Inferences were made after an analysis of BLASTP sequence similarity searches and searches for protein motifs in the PROSITE and PFAM databases (see MATERIALS and METHODS). Functions known, or inferred, from work previous to this are indicated by enclosing the gene's symbol within curly braces. The classification of functions is taken from preliminary work by the Gene Ontology Consortium (GO 1999). The complete data on which this summary is based is to be found at http://www.genetics.org/cgi/content/full/153/1/179.

 

basement membrane protein
      laminin (a2 subunit): {wb}
cyclin
      G1/S-specific cyclin: {CycE}
cytoskeletal protein
      actin binding protein: BG:DS02740.9
      cytoskeletal regulatory protein: Sop2	
electron transfer protein
      cytochrome P450: BG:DS00180.11; l(2)35Fb
enzyme
      acylphosphatase: Acyp
      adenosinetriphosphatase: BG:DS06874.3
      alcohol dehydrogenase: {Adh}
      aspartate 1-decarboxylase: b
      carbonate dehydratase: BG:DS00941.1
      double-stranded RNA specific editase: BG:DS00941.2
      glycerol 3-phosphate dehydrogenase (mitochondrial): BG:DS08249.2
      long-chain-fatty-acid-CoA-ligase: BG:DS01514.2; BG:DS05899.1
      mRNA (guanine-N7)-methyltransferase: l(2)35Bd
      polypeptide N-acetylgalactosaminyltransferase: l(2)35Aa
      protein disulfide isomerase: BG:DS09218.4
      serine esterase: Gli
      serine C-palmitoyltransferase: lace
      short chain dehydrogenase: Adhr
      ubiquitin--protein ligase: BG:DS01486.1
      endopeptidase
  	    metallopeptidase
   		   membrane alanine aminopeptidase: BG:DS00365.1
   	           metallopeptidase (M12, ADAM10 subfamily): {kuz}
   		   metallopeptidase (M12A, astacin subfamily): BG:BACR44L22.1; 
			   BG:BACR44L22.2; BG:BACR44L22.3; BG:BACR44L22.4; 
			   BG:BACR44L22.6; BG:BACR44L22.8
   		   peptidyl-dipeptidase A (M2 family): {Ance}; BG:DS00180.5
  	    serine-type peptidase: BG:DS06874.4; BG:DS06874.6; 
		   BG:DS07108.1;  BG:DS07108.5; BG:DS07486.3; BG:DS01068.10
   	    serine carboxypeptidase: BG:DS00365.3
      DNA-directed DNA polymerase
 	    mitochondrial (gamma) DNA-directed DNA polymerase
                   (accessory-subunit): {MtPolB}
  	    mitochondrial (gamma) DNA-directed DNA polymerase 
                   (catalytic-subunit): tamas
      DNA-directed RNA polymerase
  	    DNA-directed RNA polymerase II (RBP3-subunit): RpII33
      protein serine/threonine kinase
  	    protein serine/threonine kinase: smi35A
  	    receptor signalling protein serine/threonine kinase
   		   MAP kinase: p38b
      protein tyrosine phosphatase
  	    protein tyrosine phosphatase: {twe}
  	    prenylated protein tyrosine phosphatase: PRL-1 
growth factor
      imaginal disc growth factor: {Idgf1}; {Idgf2}; {Idgf3} 
motor protein
      myosin VIIA: {ck}
nucleic acid binding protein
      RNA binding protein: {BicC}
  	    ATP dependent RNA helicase: {vas}; l(2)35Df
      DNA binding protein: cact
  	    ATP dependent DNA helicase: BG:DS09217.6
   	    origin recognition complex protein
  		   origin recognition complex protein (subunit 5): {Orc5}
  	    protamine: Mst35Ba; Mst35Bb
  	    transcription factor: crp; {dac}; elB; {esg}; noc; {sna}; {stc}; {Su(H)}; wor
   		   general transcription factor associated protein: BG:DS00929.3
   	    transcription elongation factor
   		   transcription elongation factor TFIIS: TfIIS
 	    DNA repair protein
  		   DNA mismatch repair protein: {spel1}
receptor
      G protein linked receptor: rk
      GABA-A receptor: BG:DS00929.6
      nicotinic acetylcholine receptor: BG:DS05899.4
receptor signalling protein
      GTPase
  	    RAB small GTPase: Rab14
      small GTPase regulatory/interacting protein
  	    small GTPase regulatory/interacting protein: BG:BACR48E02.4
      guanyl-nucleotide exchange factor
  	    ARF guanyl-nucleotide exchange factor: BG:DS00797.7
   	    RAS guanyl-nucleotide exchange factor: {Sos}
ribosomal protein
      mitochondrial ribosomal protein
  	    large-subunit mitochondrial ribosomal protein (L4): l(2)35Fe
structural protein
      mitochondrial outer membrane component: BG:DS06874.3
      pupal cuticle protein: BG:DS06238.4
transporter
      carrier type transporter
  	    ATP-binding cassette (ABC) transporter: BG:DS00797.5
      cation/amino-acid symporter
  	    cation/amino-acid symporter: BG:DS03431.1
      cation/sugar symporter
   	    sodium/phosphate cotransporter: BG:DS07660.1
      endosomal small-molecule carrier or transporter: BG:DS00797.1
      channel type transporter
 	    calcium channel
   		   calcium channel: BG:DS07473.1
  		   voltage-gated calcium channel (subunit): BG:DS07108.2
  		   voltage-gated calcium channel (alpha 1 subunit): {Ca-a1D}
  	    sodium channel
   		   voltage-gated sodium channel: {ppk}
  	    purinoreceptor-channel
   		   nicotinic acetylcholine receptor: BG:DS05899.4
      intracellular transport protein
 	    syntaxin: Sed5
      metal ion transporter: BG:DS07295.1
      mitochondrial small-molecule carrier or transporter
 	    mitochondrial inner membrane translocase (subunit 17): Tim17