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Originally published as Genetics Published Articles Ahead of Print on June 18, 2008.
Genetics, Vol. 179, 1705-1712, July 2008, Copyright © 2008
doi:10.1534/genetics.107.085654
The Direction of Linkage Disequilibrium: A New Measure Based on the Ancestral-Derived Status of Segregating Alleles
K. Ryo Takahasi*,1 and
Hideki Innan
,1,2
* Population and Quantitative Genomics Team, Genomic Sciences Center, RIKEN, Yokohama 230-0045, Japan and Department of Evolutionary Studies of Biological Systems, Graduate University for Advanced Studies, Hayama 240-0193, Japan
2 Corresponding author: Department of Evolutionary Studies of Biological Systems, Graduate University for Advanced Studies, Hayama 240-0193, Japan.
E-mail: innan_hideki{at}soken.ac.jp
A new measure of directional linkage disequilibrium is developed for detecting epistatic selection on interacting genes. Simulations show that by orienting the direction of linkage disequilibrium on the basis of the ancestral-derived status of alleles, the new measure indeed improves the power to detect a positive fitness interaction between two new mutations.