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Genetics, Vol 124, 317-329, Copyright © 1990
INVESTIGATIONS |
The Relationship Between P Elements and Male Recombination in Drosophila melanogaster
A. Duttaroy, M. McCarron, K. Sitaraman, G. Doughty and A. Chovnick
Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06268
P element dysgenesis associated male recombination in Drosophila was examined with a selective system focused upon 5% of the standard female genetic map divided into eight recombination segments. We found no correspondence between P element mobilization events and recombination in males in the intervals monitored. We defined two adjacent short genetic and molecular regions, one devoid of male recombination and the other acting as a ``hot spot'' for exchange in the absence of supporting P element insertion and excision activity. These data suggest that, even in the presence of mobilizing P elements, transposase may be active at non-P element sites, and that the genome may harbor sequences ranging from highly responsive to completely unresponsive to transposase action. A viewpoint is presented wherein P elements, with sequences that bind transposase, serve to focus the recombination action of transposase to encompass a region of DNA radiating outward from the initial binding site. We suggest that this region is measured in terms of chromosomal segments rather than limited to P element sequences.
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