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Genetics, Vol 124, 7-25, Copyright © 1990
INVESTIGATIONS |
Mechanisms of Gene Conversion in Saccharomyces cerevisiae
H. Roman and M. M. Ruzinski
Deceased.
In red-white sectored colonies of Saccharomyces cerevisiae, derived from mitotic cells grown to stationary phase and irradiated with a light dose of x-rays, all of the segregational products of gene conversion and crossing over can be ascertained. Approximately 80% of convertants are induced in G(1), the remaining 20% in G(2). Crossing over, in the amount of 20%, is found among G(1) convertants but most of the crossovers are delayed until G(2). About 20% of all sectored colonies had more than one genotype in one or the other sector, thus confirming the hypothesis that conversion also occurs in G(2). The principal primary event in G(2) conversion is a single DNA heteroduplex. It is suggested that the close contact that this implies carries over to G(2) when crossing over and a second round of conversion occurs.
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