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Genetics, Vol 124, 145-156, Copyright © 1990
INVESTIGATIONS |
Aristapedioid: A Gain of Function, Homeotic Mutation in Drosophila melanogaster
B. P. Brunk and P. N. Adler
Department of Biology, Molecular Biology Institute, and Cancer Center, University of Virginia, Charlottesville, Virginia 22901
The isolation of gain of function mutations has allowed the identification of a number of genes which are important in the normal development of the organism. We report here the isolation and characterization of Aristapedioid, a gain of function mutation which causes a partial transformation of arista towards tarsus and the loss or decrease in size of the dorso-central and scutellar bristles. Aristapedioid is the result of a P element mediated inversion which juxtaposes unrelated DNA adjacent to Suppressor 2 of zeste, causing a gain of function mutation in that gene.
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