- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Raymond, M.
- Articles by Scott, J. G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Raymond, M.
- Articles by Scott, J. G.
Genetics, Vol 123, 543-551, Copyright © 1989
INVESTIGATIONS |
Interactions Between Pesticide Genes: Model and Experiment
M. Raymond, D. G. Heckel and J. G. Scott
Laboratoire de Genetique, Institut des Sciences de l'Evolution, 34060 Montpellier, France
In response to years of intense selection pressure by organophosphate insecticides, several different insecticide resistance mechanisms have evolved in natural populations of the mosquito Culex pipiens. We examined interactions between two of the most important mechanisms using a four-compartment model of insecticide pharmacokinetics. The joint effect of different mechanisms of resistance can be expressed in terms of epistasis at the physiological level in this model. The type of epistasis predicted by the model depends on the particular physiological mechanisms of resistance involved. Resistance due to a reduced penetration of the insecticide combines multiplicatively with other resistance factors, but resistance due to detoxicative processes and to insensitivity of the target site combines additively. How the pattern of epistasis at the physiological level is translated into fitness epistasis in natural populations of this mosquito depends on the intensity and pattern of insecticide selection in the field.
This article has been cited by other articles:
 |
|
 |
|
  F. Roux, C. Camilleri, S. Giancola, D. Brunel, and X. Reboud Epistatic Interactions Among Herbicide Resistances in Arabidopsis thaliana: The Fitness Cost of Multiresistance Genetics, November 1, 2005; 171(3): 1277 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Schlipalius, Q. Cheng, P. E. B. Reilly, P. J. Collins, and P. R. Ebert Genetic Linkage Analysis of the Lesser Grain Borer Rhyzopertha dominica Identifies Two Loci That Confer High-Level Resistance to the Fumigant Phosphine Genetics, June 1, 2002; 161(2): 773 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lenormand, T. Guillemaud, D. Bourguet, and M. Raymond Evaluating Gene Flow Using Selected Markers: A Case Study Genetics, July 1, 1998; 149(3): 1383 - 1392. [Abstract] [Full Text] [PDF]
|
|