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Genetics, Vol 123, 535-541, Copyright © 1989
INVESTIGATIONS |
Regulation of Behavioral and Pheromonal Aspects of Sex Determination in Drosophila melanogaster by the Sex-lethal Gene
L. Tompkins and S. P. McRobert
Department of Biology, Temple University, Philadelphia, Pennsylvania 19122
We have shown that the Sex-lethal (Sxl) gene, which controls morphological aspects of sex determination in Drosophila melanogaster, also regulates sexual behavior. Chromosomal males that are hemizygous for a deletion of the entire Sxl locus perform normal courtship and synthesize the two courtship-inhibiting pheromones that normal males make. However, ectopic expression of female-specific Sex-lethal gene products drastically alters chromosomal males' ability to perform and elicit courtship and increases the probability that they will synthesize a courtship-stimulating pheromone or fail to synthesize one of the inhibitory pheromones. These observations suggest that male sexual behavior is a consequence of the Sxl gene's being functionally inactive in haplo-X flies.
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