- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Cheng, Q.
- Articles by Michels, C. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Cheng, Q.
- Articles by Michels, C. A.
Genetics, Vol 123, 477-484, Copyright © 1989
INVESTIGATIONS |
The Maltose Permease Encoded by the MAL61 Gene of Saccharomyces cerevisiae Exhibits Both Sequence and Structural Homology to Other Sugar Transporters
Q. Cheng and C. A. Michels
Department of Biology, Queens College and the Graduate School of the City University of New York, Flushing, New York 11367
The MAL61 gene of Saccharomyces cerevisiae encodes maltose permease, a protein required for the transport of maltose across the plasma membrane. Here we report the nucleotide sequence of the cloned MAL61 gene. A single 1842 bp open reading frame is present within this region encoding the 614 residue putative MAL61 protein. Hydropathy analysis suggests that the secondary structure consists of two blocks of six transmembrane domains separated by an approximately 71 residue intracellular region. The N-terminal and C-terminal domains of 100 and 67 residues in length, respectively, also appear to be intracellular. Significant sequence and structural homology is seen between the MAL61 protein and the Saccharomyces high-affinity glucose transporter encoded by the SNF3 gene, the Kluyveromyces lactis lactose permease encoded by the LAC12 gene, the human HepG2 glucose transporter and the Escherichia coli xylose and arabinose transporters encoded by the xylE and araE genes, indicating that all are members of a family of sugar transporters and are related either functionally or evolutionarily. A mechanism for glucose-induced inactivation of maltose transport activity is discussed.
This article has been cited by other articles:
 |
|
 |
|
  X. Wang, M. Bali, I. Medintz, and C. A. Michels Intracellular Maltose Is Sufficient To Induce MAL Gene Expression in Saccharomyces cerevisiae Eukaryot. Cell, October 1, 2002; 1(5): 696 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Peñalver, P. Lucero, E. Moreno, and R. Lagunas Clathrin and Two Components of the COPII Complex, Sec23p and Sec24p, Could Be Involved in Endocytosis of the Saccharomyces cerevisiae Maltose Transporter J. Bacteriol., April 15, 1999; 181(8): 2555 - 2563. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Medintz, H. Jiang, and C. A. Michels The Role of Ubiquitin Conjugation in Glucose-induced Proteolysis of Saccharomyces Maltose Permease J. Biol. Chem., December 18, 1998; 273(51): 34454 - 34462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Mehta, V. B. Patil, S. Velmurugan, Z. Lobo, and P. K. Maitra std1, a Gene Involved in Glucose Transport in Schizosaccharomyces pombe J. Bacteriol., February 1, 1998; 180(3): 674 - 679. [Abstract] [Full Text]
|
|