The Multivulva Phenotype of Certain Caenorhabditis elegans Mutants Results From Defects in Two Functionally Redundant Pathways

INVESTIGATIONS

The Multivulva Phenotype of Certain Caenorhabditis elegans Mutants Results From Defects in Two Functionally Redundant Pathways

E. L. Ferguson and H. R. Horvitz
Present address: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720.

We previously identified Caenorhabditis elegans mutants in which certain of the six vulval precursor cells adopt fates normally expressed by other vulval precursor cells. These mutants define genes that appear to function in the response to an intercellular signal that induces vulval development. The multivulva (Muv) phenotype of one such mutant, CB1322, results from an interaction between two unlinked mutations, lin-8(n111) II and lin-9(n112) III. In this paper, we identify 18 new mutations, which are alleles of eight genes, that interact with either lin-8(n111) or lin-9(n112) to generate a Muv phenotype. None of these 20 mutations alone causes any vulval cell lineage defects. The ``silent Muv'' mutations fall into two classes; hermaphrodites carrying a mutation of each class are Muv, while hermaphrodites carrying two mutations of the same class have a wild-type vulval phenotype. Our results indicate that the Muv phenotype of these mutants results from defects in two functionally-redundant pathways, thereby demonstrating that redundancy can occur at the level of gene pathways as well as at the level of gene families.

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				C. Cayrol, C. Lacroix, C. Mathe, V. Ecochard, M. Ceribelli, E. Loreau, V. Lazar, P. Dessen, R. Mantovani, L. Aguilar, et al. The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes Blood, January 15, 2007; 109(2): 584 - 594. [Abstract] [Full Text] [PDF]

				M. Pilkinton, R. Sandoval, J. Song, S. A. Ness, and O. R. Colamonici Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1 J. Biol. Chem., January 5, 2007; 282(1): 168 - 175. [Abstract] [Full Text] [PDF]

				M. M. Harrison, C. J. Ceol, X. Lu, and H. R. Horvitz Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex PNAS, November 7, 2006; 103(45): 16782 - 16787. [Abstract] [Full Text] [PDF]

				B. P. Gupta, J. Liu, B. J. Hwang, N. Moghal, and P. W. Sternberg sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans Genetics, November 1, 2006; 174(3): 1315 - 1326. [Abstract] [Full Text] [PDF]

				S. M. Lauberth and M. Rauchman A Conserved 12-Amino Acid Motif in Sall1 Recruits the Nucleosome Remodeling and Deacetylase Corepressor Complex J. Biol. Chem., August 18, 2006; 281(33): 23922 - 23931. [Abstract] [Full Text] [PDF]

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				E. C. Andersen, X. Lu, and H. R. Horvitz C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates Development, July 15, 2006; 133(14): 2695 - 2704. [Abstract] [Full Text] [PDF]

				C. J. Ceol, F. Stegmeier, M. M. Harrison, and H. R. Horvitz Identification and Classification of Genes That Act Antagonistically to let-60 Ras Signaling in Caenorhabditis elegans Vulval Development Genetics, June 1, 2006; 173(2): 709 - 726. [Abstract] [Full Text] [PDF]

				P. W. Sternberg Pathway to RAS. Genetics, February 1, 2006; 172(2): 727 - 731. [Full Text] [PDF]

				M. A. Chesney, A. R. Kidd III, and J. Kimble gon-14 Functions With Class B and Class C Synthetic Multivulva Genes to Control Larval Growth in Caenorhabditis elegans Genetics, February 1, 2006; 172(2): 915 - 928. [Abstract] [Full Text] [PDF]

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				P. W. Lewis, E. L. Beall, T. C. Fleischer, D. Georlette, A. J. Link, and M. R. Botchan Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex Genes & Dev., December 1, 2004; 18(23): 2929 - 2940. [Abstract] [Full Text] [PDF]

				J. Yochem, L. R. Bell, and R. K. Herman The Identities of sym-2, sym-3 and sym-4, Three Genes That Are Synthetically Lethal With mec-8 in Caenorhabditis elegans Genetics, November 1, 2004; 168(3): 1293 - 1306. [Abstract] [Full Text] [PDF]

				G. R. Miley, D. Fantz, D. Glossip, X. Lu, R. M. Saito, R. E. Palmer, T. Inoue, S. van den Heuvel, P. W. Sternberg, and K. Kornfeld Identification of Residues of the Caenorhabditis elegans LIN-1 ETS Domain That Are Necessary for DNA Binding and Regulation of Vulval Cell Fates Genetics, August 1, 2004; 167(4): 1697 - 1709. [Abstract] [Full Text] [PDF]

				M. Cui, D. S. Fay, and M. Han lin-35/Rb Cooperates With the SWI/SNF Complex to Control Caenorhabditis elegans Larval Development Genetics, July 1, 2004; 167(3): 1177 - 1185. [Abstract] [Full Text] [PDF]

				D. Garbe, J. B. Doto, and M. V. Sundaram Caenorhabditis elegans lin-35/Rb, efl-1/E2F and Other Synthetic Multivulva Genes Negatively Regulate the Anaphase-Promoting Complex Gene mat-3/APC8 Genetics, June 1, 2004; 167(2): 663 - 672. [Abstract] [Full Text] [PDF]