- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by McGill, S.
- Articles by Ashburner, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by McGill, S.
- Articles by Ashburner, M.
Genetics, Vol 119, 647-661, Copyright © 1988
INVESTIGATIONS |
The Molecular Analyses of an Antimorphic Mutation of Drosophila melanogaster, Scutoid
S. McGill, W. Chia, R. Karp and M. Ashburner
Present address: Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway.
A dominant mutation of Drosophila melanogaster, Scutoid (Sco), acts as an antimorphic allele of the no-ocelli (noc) gene. In Sco the noc region has been transposed from 35B to 35D on chromosome arm 2L and the noc gene is now adjacent to snail (sna). Induced revertants of Sco are frequently mutant for sna or are aberrations broken very close to sna. A molecular analysis of the Sco chromosome has confirmed that noc is transposed and fused to the sna region. However, only part of the noc region is included within the transposition. The breakpoints of 19 chromosomally aberrant Sco revertants have been mapped at the molecular level. Fourteen of these breakpoints map to the noc region, spread over about 80 kb of DNA. The breakpoints of the remaining five are not within the DNA of the noc region and appear to map within sequences from the sna region. This has been shown directly for three of these, those associated with T(2;3)Sco(R+13), In(2L)Sco(R+24) and In(2L)Sco(R+26). Thus mutation of either noc or sna, genes which are apparently unrelated in their wild-type functions, can revert the antimorphic phenotype of Sco.
This article has been cited by other articles:
 |
|
 |
|
  B. Grau, C. Popescu, L. Torroja, D. Ortuno-Sahagun, I. Boros, and A. Ferrus Transcriptional Adaptor ADA3 of Drosophila melanogaster Is Required for Histone Modification, Position Effect Variegation, and Transcription Mol. Cell. Biol., January 1, 2008; 28(1): 376 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ashburner, S. Misra, J. Roote, S. E. Lewis, R. Blazej, T. Davis, C. Doyle, R. Galle, R. George, N. Harris, et al. An Exploration of the Sequence of a 2.9-Mb Region of the Genome of Drosophila melanogaster: The Adh Region Genetics, September 1, 1999; 153(1): 179 - 219. [Abstract] [Full Text]
|
|