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Genetics, Vol 119, 365-375, Copyright © 1988
INVESTIGATIONS |
X Chromosome Duplications Affect a Region of the Chromosome They Do Not Duplicate in Caenorhabditis elegans
P. M. Meneely and K. D. Nordstrom
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress an X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, although these two genes are located in a region of the X chromosome that is not duplicated. The effects do not depend on the region of the X chromosome duplicated and is stronger in strains with two doses of a duplication than in strains with one dose. This is evidence for a general elevation of X-linked gene expression in strains carrying X-chromosome duplications, consistent with the hypothesis that the duplications titrate a repressor acting on many X-linked genes.
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