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Genetics, Vol 119, 85-94, Copyright © 1988
INVESTIGATIONS |
Molecular Analysis of an Unstable P Element Insertion at the singed Locus of Drosophila melanogaster: Evidence for Intracistronic Transposition of a P Element
R. S. Hawley, R. A. Steuber, C. H. Marcus, R. Sohn, D. M. Baronas, M. L. Cameron, A. E. Zitron and J. W. Chase
Department of Genetics and Department of Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461
In a companion study, a number of P element insertions into the singed locus were characterized. Here is reported a detailed analysis of the structure and mutability of another P element insertion at sn, known as sn(cm). Under conditions which mobilize P elements, sn(cm) mutates at high frequency to both wild-type (sn(+)) and to a much more extreme allele (sn(ext)). Wild-type revertants appear to represent precise or nearly precise excisions of the P element. Certainly two, and most likely all five, of the sn(ext) alleles studied result from the insertion of a duplicate copy of this P element into a nearby site in an inverted orientation. We propose a model in which both the sn(+) and sn(ext) mutational events can be explained by excision of the P element from one chromatid followed by reintegration into the sister chromatid at a nearby site (intracistronic transposition). Finally, it is shown that the sn(ext) alleles are themselves unstable and the structure of a resulting chromosome aberration is examined.
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