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Drosophila Mitochondrial Genetics: Evolution of Heteroplasmy Through Germ Line Cell Divisions
Michel Solignac 1, Jean Génermont 2, Monique Monnerot 3, and Jean-Claude Mounolou 3
1 Laboratoire de Biologie et Génétique Evolutives,
Centre National de la Recherche Scientifique, F 91190 Gif-sur-Yvette, France
2 Laboratoire de Zoologie II
3 Laboratoire de Biologie Générale, Université
de Paris XI, F 91405, Orsay, France
The mitochondrial genotype of all F1 female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovariole stem cells at the end of development. Cohorts of females from the eggs laid day after day by this female, throughout the 31 days of its life, provide information on the evolution of the mitochondrial genotypes in the course of successive divisions of stem cells. An increase of the percentage of long DNA in offspring was observed as the female aged. Moreover, the variance of the genotypes increases as rounds of stem cell division progress. These results are supported by observations based on the adults issued from the early and late eggs, for three additional heteroplasmic females.
Submitted on May 27, 1987Accepted on August 19, 1987
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